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Firke, S. D.
- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
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Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.
References
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- Overview on Acquired Immunodeficiency Syndrome
Abstract Views :176 |
PDF Views:7
Authors
Affiliations
1 NGSPMs College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IN
1 NGSPMs College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 158-162Abstract
Acquired immunodeficiency syndrome (AIDS) causes an irreversible destruction of immune system. Currently, used drugs for treatment of HIV/AIDS act through inhibition of important viral enzymes such as reverse transcriptase, protease and/or integrase. Uncoating inhibitor has also been approved for treatment of AIDS with novel mode of action. However, it is now evident that the existing armoury of antiretroviral and even their triplet (cocktail) and/or quadruple (highly active antiretroviral therapy, HAART), will not lead to eradication of HIV infection. Therefore recently scientists have proposed different targets and treatment approaches towards the HIV/AIDS, which include entry inhibitors, transcription inhibitors, uncoating inhibitors, zinc finger inhibitors, gene therapy.Keywords
AIDS, Life Cycle, Recent Targets.References
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- De Clercq E.; New anti-HIV agents and targets; Med Res Rev., 2002 Nov, 22(6), 531-65.
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- Turpin JA., The next generation of HIV/AIDS drugs: novel and developmental anti-HIV drugs and targets, Expert Rev Anti Infect Ther., 2003 Jun, 1(1), 97-128.
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- Zinc finger inhibitor for HIV, Treat Rev, 1996 Dec, (No 23), 13
- De Clercq E., New anti-HIV agents and targets, Med Res Rev., 2002 Nov, 22(6), 531-65.
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- Barichievy S., Saayman S., Arbuthnot P., Weinberg M. S., RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV, Curr Top Med Chem. 2009, 9(12),1065-78.
- Novel gene therapy for aids using mutated tRNAs, Reference: UCLA Case No. 1993-564, US Patent Number: 6,355,790
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- Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin
Abstract Views :184 |
PDF Views:0
Authors
S. M. Sarode
1,
G. Vidya Sagar
2,
M. K. Kale
3,
P. K. Nimase
4,
A. P. Kulkarni
3,
S. D. Firke
3,
B. M. Firke
3,
P. D. Warke
3,
M. A. Chaudhari
3
Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 173-177Abstract
The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.Keywords
Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.- Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188
Abstract Views :157 |
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Authors
D. S. Saindane
1,
A. S. Kulkarn
2,
A. N. Sagri
2,
R. B. Pimprikar
3,
S. B. Yeshwante
3,
C. P. Suryawanshi
3,
S. D. Firke
4,
M. K. Kale
4
Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 162-166Abstract
This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.Keywords
Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.- Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones
Abstract Views :172 |
PDF Views:0
Authors
Affiliations
1 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), IN
2 TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), IN
1 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), IN
2 TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), IN